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Related Diseases
> Heart Problems
Overview
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Since the
kidneys and heart are closely related, heart problems are relatively
common in CKD cats.
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This page
covers the three main heart problems you may be faced with: heart murmurs,
hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF).
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Although it is
a delicate balance, because the treatment for the heart condition may put
additional strain on the kidneys and vice versa, it is often worth trying
treatment.
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Treating the
heart must always take precedence.
Heart
Murmurs
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A heart murmur
occurs when blood flows through the heart turbulently rather than
smoothly. Heart murmurs are graded from 1 to 6 depending
upon their severity: 1 is the lowest level at which a murmur can
be heard by the vet, while 6 is the most severe and is an extremely loud murmur which is
often audible without a stethoscope.
Heart murmurs
may or may not need treatment, depending upon their cause and their
severity. Both anaemia and
hyperthyroidism
may cause a heart murmur which disappears following treatment of the
underlying problem. Some cats have heart murmurs because
they have a type of heart disease called
hypertrophic cardiomyopathy, but it is also possible to have a heart
murmur without having HCM - Prevalence
of cardiomyopathy in apparently healthy cats (2009 Paige CF,
Abbott JA, Elvinger F & Pyle RL Journal of the American Veterinary
Medical Association 234(11) pp1398-1403 found that "in
apparently healthy cats, detection of a heart murmur is not a reliable
indicator of cardiomyopathy."
Merck
Veterinary Manual has detailed
information on heart murmurs.
Colorado State University lets you listen
to feline heart sounds.
Pet Place has some information on heart
murmurs (no need to register, just click Close at the bottom of the
annoying pop up).
Veterinary Partner has information on
heart murmurs and allows you to listen to a normal heart and to one with a
murmur.
University
of California at Los Angeles lets you listen to the different types of heart
murmur - turn your speakers up loud for best effect. This is a human site
but it should still give you an idea of what to listen for.
Hypertrophic Cardiomyopathy (HCM)
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Cardiomyopathy means disease of the heart
muscle, and in hypertrophic cardiomyopathy the left ventricle of the heart,
which pumps blood through the aorta, the body's largest artery, is
thickened. This thickening stops the heart expanding properly.
HCM may be
caused by an overactive thyroid - in fact,
Gulf Coast Veterinary Specialists claim
that 87% of hyperthyroid cats will have some degree of HCM. Other possible
causes include high blood pressure or
CKD,
while in some breeds, such as Maine
Coons or Ragdolls, HCM is a genetic problem -
The Winn Feline Foundation explains more
about this. However, it is
also possible for a cat to have HCM without any associated disease.
HCM can often
be managed with heart medications.
Feline cardiomyopathies - an update
(2009) is a presentation by Anne French to the World Small Animal
Veterinary Association World Congress which describes the various
types of cardiomyopathy.
Congestive
Heart Failure (CHF)
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As heart
disease and/or renal disease progress, congestive heart
failure may develop. In CHF, the heart is really struggling to cope and fluid may
accumulate:
The risk of CHF
is higher if a cat has
anaemia.
It may also occur if a cat is
overhydrated via
too much sub-Q fluids. Sub-Qs are not a benign treatment
and should only be given when necessary and not in large quantities. You can
read more about what to watch for
here.
If your cat develops CHF within a week of starting
corticosteroids, this might possibly be the cause. One study,
Corticosteroid-associated congestive heart failure in
12 cats (2004) Smith SA, Tobias AH,
Fine DM, Jacob KA, Ployngam T The International Journal of Applied
Research in Veterinary Medicine 2 (3) pp159-170 found that some
cats developed a unique form of
congestive heart failure (CHF) within seven days of starting steroids.
Five of the cats died, but the seven that survived did much better than the
typical CHF patient once taken off the steroids.
If you suspect CHF, you should seek veterinary help as soon as possible.
See below for possible
symptoms.
Sadly, many cats with CHF only have a short
period to live, although it is usually worth trying to control the
condition because, as with CKD, some cats do better than others. Treatment
commonly includes the use of
diuretics.
Pet Place
has some information about pleural effusion (you don't need to register to
read the article, just click on the Close This Window link at the bottom
of the registration pop-up).
Macmillan Cancer Support
explains more about pleural
effusion.
Pet MD discusses pulmonary oedema in
cats.
Pet MD has
information about ascites.
Health A to Z explains more about
ascites.
Warning signs for congestive heart failure is a helpful site by an
individual whose cat, Coco, had both CKD and heart problems, and gives
useful information on what to watch for. Coco lived with CHF for quite
some time.
Emergency respiratory assessment (2001)
Hughes D is a presentation to the World Small Animal Veterinary
Association World Congress 2001. It is rather technical but may still be
of use.
Diagnosis
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If heart
problems are suspected, ideally you want to see a veterinary cardiologist
to obtain an accurate diagnosis and a personalised treatment plan.
Cavalier Health has details of
veterinary cardiologists in the USA, Canada and the UK.
A heart murmur
is detected via a stethoscope, but if your vet wishes to investigate it
further, additional tests can be performed, such as x-rays or ultrasound.
X-rays are the
only way to diagnose pleural effusion, pulmonary oedema or ascites, all
commonly seen in
congestive heart failure.
Idexx Laboratories offers a new
blood test which checks levels of a peptide called NTproBNP, which it
states "can be clinically useful as an initial screening test for cats
with suspected cardiac disease. However, one study,
NT-proBNP measurement fails to reliably identify
subclinical hypertrophic cardiomyopathy in Maine Coon cats
(2011) Singh MK, Cocchiaro MF, Kittleson MD Journal of Feline
Medicine & Surgery 12 p942, found that "56%
of cats with severe disease in this study would have been considered
normal based on a NT-proBNP concentration; the sensitivity for diagnosing
severe disease was only 44% (at a cutoff of ≤100 pmol/l). For any
other condition less than severe HCM, the measurement of NT-proBNP
concentration was found to be insensitive. Cats with equivocal and
moderate disease were not identified by this assay." Therefore,
whilst this test may be a useful starting point, I would not rely on it
alone. The only way to
obtain a definitive diagnosis of HCM is by way of echocardiogram (ultrasound), ideally with Doppler colour flow imaging. If you cannot visit
a veterinary cardiologist, it is sometimes possible for your own vet to
perform the ultrasound and send the images through to a veterinary
cardiologist for interpretation.
Laboratory tests for the diagnosis of heart disease
and failure in dogs and cats (2007) is a presentation by A
Boswood to the World Small Animal Veterinary Association World Congress
2007 which discusses the use of the NTproBNP test.
The
Feline Advisory Bureau
in conjunction with the
Veterinary
Cardiovascular Society has set up an HCM screening scheme for UK cats.
Feline cardiomyopathy - establishing a diagnosis
(2002) Fuentes VL, is a presentation to the 26th Annual Waltham/Ohio State
University Symposium.
Symptoms
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Unfortunately
many cats are asymptomatic or show very few symptoms, which is why it can
be hard to diagnose heart
disease.
One of our cats, Harpsie, was suspected of having heart disease because of a high heart rate on two vet visits (which
might just as easily have been caused by stress or "white coat
syndrome") and weight loss. Other possible symptoms can be similar to
those of CKD, including lack of appetite, lethargy and vomiting. You may
also see faster breathing (the normal respiratory rate of a cat is around
20-30 respirations a minute).
More Serious Symptoms
In most cases,
if you suspect heart problems, you can wait a day or two to see the vet.
However, if you see the following symptoms, you should take your cat to
the vet as soon as possible.
Saddle Thrombus (Blood Clot in the Legs)
A saddle
thrombus is a blood clot in the aorta which stops the blood supply to
the legs. Symptoms include:
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Limping or an inability to use the leg.
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The affected leg
is likely to be cold to the
touch.
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Often only
one leg is affected, but in some cases a pair of legs (e.g. both rear legs) may be
affected.
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The
affected leg is usually a rear leg, though I have heard of cats who
developed saddle thrombus in a front leg.
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Weak
legs (as opposed to limping) may also have other causes, see Index
of Symptoms and Treatments.
A saddle
thrombus is
life-threatening so you should consult a vet as
soon as possible. If your vet proposes a treatment plan, make sure it
includes painkillers because this is an extremely painful condition.
Heart medications such as Plavix (clopidogrel) and blood thinners are
also commonly prescribed.
University of California at Davis has
some information on blood clots in cats.
Manhattan Cats also has some detailed
information on blood clots, including possible treatment options.
Pet Place has a good overview of
saddle thrombus (no need to register to read it, just click the Close
button at the bottom of the pop-up).
Systemic arterial embolism in cats
(2007) is a presentation by Dr C Atkins to the World Small Animal
Veterinary Association World Congress 2007 which discusses
treatment and prevention.
Feline thromboembolism - new clinical
perspectives (2007) is a presentation by Dr PR Fox to the
World Small Animal Veterinary Association World Congress 2007
which discusses treatment options.
The American Association of Feline Practitioners
reports on a trial led by Dr Dan Hogan of Purdue University College of
Veterinary Medicine into the use of Plavix versus aspirin in cats who
have previously thrown a clot. New applicants are welcome.
Fluid Build-Up/Congestive Heart Failure
Signs of fluid
build up, which are often a sign of congestive heart failure, include:
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sudden
weight gain
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coughing
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difficulty
breathing
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fast
breathing
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open mouth
breathing
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loss of
appetite (the fluid makes the cat feel full)
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The cat may
sit up and refuse to lie down; this is because it is easier to breathe
in this position
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A low body
temperature may also be seen in congestive heart failure, so the cat
may seek out warm places
If your cat has CHF, it is
worth asking your vet to teach you to listen to your cat's heart so you
can monitor for any changes that might indicate an approaching crisis.
Regular x-rays can also be helpful to avoid crises, though you need to
balance the need for these against the stress of vet visits. See
below for treatments.
Treatments
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How cats cope with heart disease varies from cat to cat, depending upon
how advanced the disease is and how well the cat responds to treatment,
but in most cases I would say it is worth trying treatment. Anything that
may be contributing to the heart problems, such as
anaemia,
hyperthyroidism and
hypertension, should be treated - in some cases, this
may actually be all that is necessary. Try to keep stress to a minimum.
Washington State University College of Veterinary
Medicine has some suggestions on how to care for a heart
patient at home.
Mar Vista Vet has information on long
term therapy for heart failure.
Managing concurrent kidney and heart disease
(2009) is an article by Jessica Tremayne in the October 2009 issue
of Veterinary Practice News, which includes some information on
diets for patients with both kidney and heart disease.
Congestive Heart Failure Treatments
If left
untreated, fluid build-up can kill, so the fluid should be removed. For immediate relief, thoracocentesis (needle
aspiration) may be performed: this entails inserting a fine needle
into the chest or abdomen and drawing the fluid off. It sounds horrible, but my
cat had this done to remove ascites (fluid in the abdomen) and he didn't even flinch.
However, it is a delicate procedure, and skill is required to insert
the needle in the right place and remove the correct amount of fluid.
Once the
excess fluid has been removed, medications known as
duretics are commonly
used to prevent the fluid building up too much in the future. These
are often used in conjunction with other heart medications, especially
ACE inhibitors.
Vetgo discusses the usual treatments for
congestive heart failure.
Mar Vista Vet has information on long
term therapy for heart failure.
Effect of coenzyme Q10 therapy in patients with
congestive heart failure: a long-term multicenter randomised study
(1993)
Morisco C,
Trimarco B,
Condorelli M Clinical Investigation
71 (8 Supp) pp134-6 demonstrated "that the addition of coenzyme Q10
to conventional therapy significantly reduces hospitalization for
worsening of heart failure and the incidence of serious complications in
patients with chronic congestive heart failure".
HCM Treatments
HCM cannot be cured
but it can be controlled by way of drugs. Unfortunately many drugs which help the heart
condition put strain on the kidneys, so if your cat has both heart disease
and CKD, discuss which drug to use with your vet. It must be emphasised
that it is essential to treat heart disease if it is present, and that
treating the heart disease must take precedence over treating the CKD,
which is an academic problem if the heart stops beating.
Even if your
cat appears stable once medication has begun, it is a good idea to have an
ultrasound examination of your cat's heart undertaken once every year (or
more regularly if your cardiologist advises it) and
to review medication at that time if appropriate.
Commonly
Used Heart Medications
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HCM is usually
treated with drugs and it is fairly common to use more than one heart
medication at a time. The different
drug classes are:
ACE inhibitors
Calcium channel blockers
Bronchodilators
Diuretics
Aspirin
Feline
cardiomyopathies (2001) is a paper
presented by Dr Paul Pion to the World Small Animal Veterinary Association
World Congress in 2001, which gives
typical heart drug dosages.
Some people
also use an antioxidant called Coenzyme Q10 or CoQ10. There is more
information about this
here.
Beta
Blockers
Beta blockers are used to slow a fast heart rate.
Atenolol is commonly used in the USA. In the UK, a similar drug called Propranolol may be used.
Pharmacokinetics of atenolol in clinically normal
cats (1996) Quinones M, Dyer DC, Ware WA & Mehvar R American
Journal of Veterinary Research 57(7) pp1050-3 discusses the
effects of atenolol on cats.
ACE (Angiotensin-Converting-Enzyme)
Inhibitors
These are drugs which prevent the conversion of a hormone called
angiotensin I into another hormone called angiotensin II, the role of
which is to constrict blood vessels. Therefore by using these drugs
the blood vessels relax and this makes it easier for the heart to pump
blood through the body. You should be
careful if you are using ACE inhibitors at the same time as
potassium
supplements, because they may cause potassium levels to become
dangerously high.
ACE inhibitors are a popular treatment for
heart disease, and a commonly used one is enalapril, the trade name of which is
Enacard. Mar
Vista
Vet
has information and cautions on the use of Enalapril, including when
using it in conjunction with diuretics such as frusemide (US:
furosemide) (see below).
Another ACE inhibitor,
benazepril, is licensed under the trade name of
Fortekor for the treatment of
CKD in cats in the UK,
Europe and Australia,
even for cats without heart disease. Further information about this can be found
on the
Treatments
page.
An ACE
inhibitor called Ramipril
(marketed as Altace or
Vasotop) is available in the UK
and Europe, though I only know of a couple of people who have used it for their cat. The
efficacy, tolerance and safety of the angiotensin converting enzyme
inhibitor ramipril in cats with cardiomyopathy with or without
hypertension (2002) Schille F & Skrodski M is a paper
presented to the World Small Animal Veterinary Association World
Congress 2002.
It is not
unusual for cats suffering from
congestive heart failure to be given both
an ACE inhibitor and a
diuretic.
Calcium
Channel Blockers
Calcium
channel blockers work by slowing the passage of calcium into muscle
cells; this makes muscle in the blood vessels relax, so the blood
vessels open wider. The most commonly available one is
called Diltiazem. Another
member of the calcium channel blocker family,
amlodipine, is the best choice for controlling hypertension in
cats.
Bronchodilators
Bronchodilators
are used in asthma, but may occasionally be used to treat heart problems -
they open up constricted airways in the lungs. Millophyline-V (etamiphylline)
is commonly used in the UK; theophylline is commonly used in the US
and may also be offered in the UK. Veterinary
Partner has information on the use of theophylline.
Diuretics
Diuretics
may be used for congestive heart failure in order to rid the body of
excess fluid. They are also used occasionally when a cat in the end
stages of CKD has
stopped urinating (anuria), in an attempt to "kickstart" the kidneys. The most common
diuretic used in the UK is a drug called
frusemide (furosemide in USA), which is commonly sold under the name of
Lasix, although the name is currently being changed to Salix. Lasix is very hard on the
kidneys, but some people have found that another diuretic, spironolactone,
is gentler. However, Lasix is the best choice during times of crisis.
It is not unusual for cats suffering from congestive heart failure to be
given both an ACE
inhibitor and a diuretic.
Lactulose may exacerbate the effects of diuretics.
Drugs
has more information about this.
Mar
Vista
Vet has more information on Lasix (frusemide or furosemide), including
cautions about using diuretics at the same time as ACE inhibitors.
Pet Place has more information about
spironolactone.
Aspirin
Aspirin may
be used in an attempt to reduce the chances of blood clots forming.
Aspirin can be toxic to cats, who can only metabolise it very slowly,
and should only be given to a cat on
veterinary advice; it is usually only given in very low doses once
every three days. In the USA, cats with HCM are routinely given
carefully assessed doses of aspirin in addition to other medications,
but if the cat reacts badly, then aspirin is stopped.
Mar Vista Vet
has information on aspirin.
Links
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Veterinary
Links
Long
Beach Animal Hospital - explains how the heart works, and
the Specific Diseases link discusses HCM.
Vetinfo
an overview of feline heart problems and medication by a US vet.
Vetinfo - this is a reply by the same vet to a query about the use
of the usual heart medications in cats with CKD, particularly ACE
inhibitors such as enalapril (Enacard) or benazepril (Fortekor).
Cardiorespiratory diseases of the dog and cat
is the online version of a detailed book by a veterinary cardiologist.
Other Links
Feline Advisory Bureau - an overview of HCM by the UK feline
charity.
Boo Boo's Story - this is a site about Boo Boo, a
cat who was treated for both CKD and HCM using holistic methods.
Ragdolls
- Ragdolls (and Maine Coons) can be prone to HCM, and this site has good pictures of a
healthy heart and an HCM-affected heart.
Jody Chinitz's site - this site is by a
lady
who lost a cat to HCM.
Feline Heart Group -
a support group for people with cats with heart conditions, where you can obtain feedback
on treatments, and support on living with HCM and other feline heart
problems. (Note: this group has open archives, meaning anybody can read
what you write).

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This page
last updated: 15 October 2011
Links on this page last checked: 15 October 2011
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